论文部分内容阅读
肝细胞癌(HCC)预后极差,延长患者生存期的关键是早期(小肝癌)诊断和早期(手术)治疗。HCC通过肝癌标记和影像检查建立诊断。甲胎蛋白(AFP)是主要肝癌标记,但有假阳性和假阴性;AFP异质体(AFP-L3)、AFP基因标志(AFP-mRNA)以及GGT-Ⅱ、PIVKAⅡ、AFU等其它肝癌标记可与AFP互补诊断,尤其对AFP假阴性肝癌和小肝癌的诊断甚有帮助。磷脂酰肌醇蛋白多糖-3(GPC-3)在细胞的生长发育中起重要的调控作用,与肝癌密切相关。本文就GPC-3分子构成、表达机制、与多种信号传导途径关系及对肝癌早期诊断价值等作一综述。
The prognosis of hepatocellular carcinoma (HCC) is extremely poor. The key to prolonging the survival of patients is early (small hepatocellular carcinoma) diagnosis and early (surgery) treatment. HCC establishes a diagnosis by liver cancer marker and imaging. AFP is the major marker of liver cancer, but false positive and false negative; AFP-L3, AFP gene (AFP-mRNA) and other liver cancer markers such as GGT-Ⅱ, PIVKAⅡ, Complementary diagnosis with AFP, especially for AFP false-negative liver cancer and small liver cancer diagnosis is helpful. Phosphoinositide-3 (GPC-3) plays an important regulatory role in cell growth and development, and is closely related to liver cancer. This article reviews the molecular composition of GPC-3, the mechanism of its expression, the relationship with various signal transduction pathways and the early diagnosis of liver cancer.