大骨节病、克山病、克汀病是一种病因未明的地方性疾病。大骨节病早在1926年于黑龙江省开始发现,地方上又叫“柳拐子病”。这种病多发生在冬春季节,病患者四肢关节粗大、肌肉萎缩、指短、畸形,侵害对象多为青少年,患病严重者终年遭受病痛折磨,生活不能自理,甚至造成终身残废。克山病是以心肌损伤为主的心肌病。1935年冬在黑龙江克山县发生大批妇女急 Kashin-Beck disease, Keshan disease, cretinism is a endemic disease of unknown etiology. Kashin-Beck disease began in Heilongjiang Province as early as 1926 and was also called “Lijiaozi disease” at the place. The disease occurs in winter and spring, the patient limbs and joints thick, muscle atrophy, refers to short, deformity, infringement targets are mostly young people, suffering from severe pain and suffering all year long, life can not take care of themselves, and even caused life-long disability. Keshan disease is a myocardial injury-based cardiomyopathy. The winter of 1935 in Keshan County, Heilongjiang, a large number of women urgent