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博来霉素对放射线具有增感作用,对口腔扁平上皮癌同时使用低线量(30Gy)已有治愈的病例。Pep-10mycin(PEP)是博来霉素的诱导体,与博来霉素有同样的抗癌作用,也有放射线增感作用。作者对口腔扁平上皮癌并用PEP放疗进行了研究。对象与方法1982～1984年间放疗并用PEP的共117例,占同期放疗的34%。其中舌癌33例,下颌牙龈癌27例,口底癌20例,上颌牙龈癌17例。第一次放疗为外部照射(~(60)Co-γ线)一次2Gy,周五次总线量3周共30Gy,同时并用PEP每日5mg周
Bleomycin has a sensitizing effect on radiation and has been used in the treatment of oral squamous cell carcinoma with low-line dose (30 Gy). Pep-10mycin (PEP) is an inducer of bleomycin, which has the same anticancer effect as bleomycin and also has radiation sensitization. The authors studied oral squamous cell carcinoma with PEP radiotherapy. Subjects and Methods A total of 117 cases of radiotherapy and PEP were used between 1982 and 1984, accounting for 34% of radiotherapy during the same period. There were 33 cases of tongue cancer, 27 cases of mandibular gingival cancer, 20 cases of floor cancer, and 17 cases of maxillary gingival cancer. The first radiotherapy was external irradiation (~(60)Co-γ line) once every 2Gy, and the number of busses was 30Gy for 3 weeks on Friday, and 5mg daily with PEP.