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目的分析中国大陆首例输入性寨卡病毒感染病例的临床表现及实验室检测结果,为寨卡病毒病的预防控制提供参考依据。方法通过对病例进行流行病学个案调查,收集相关病历资料,并开展相关实验室检测,应用描述性流行病学方法对病例的临床表现及实验室检测结果进行分析。结果病例男性,34岁于2016年2月2日从委内瑞拉出发,途经中国香港、广东省深圳和东莞,于2月5日抵达江西省赣州市赣县,2月6日被收入赣县人民医院感染性疾病科接受隔离治疗,2月14日痊愈出院;病例临床表现为发热、头晕头痛、畏寒、乏力、皮疹、眼眶痛、结膜充血、腹泻等症状;病例白细胞和血小板值正常,单核细胞比率略有升高,凝血酶原时间略有升高,肝肾功能检查白蛋白、尿素氮、尿酸略有下降,左下肺轻度肺气肿改变;病原学检测结果显示,病例尿液标本寨卡病毒核酸存在时间较血清标本长,发病第15 d病例唾液标本未检出核酸阳性。结论本例病例为一典型但症状较轻的输入性寨卡病毒感染病例,对具有流行病学史且同时出现发热或皮疹等症状的归国人员进行排查,采集其血清、尿液等多种标本进行检测,有利于病例的早期发现、诊断和治疗。
Objective To analyze the clinical manifestations and laboratory test results of the first case of imported Zika virus infection in mainland China and provide reference for the prevention and control of Zika virus disease. Methods Through case investigation of epidemiological cases, relevant medical records were collected and related laboratory tests were carried out. Descriptive epidemiological methods were used to analyze the clinical manifestations and laboratory test results. Results Case Male, 34 years old, started from Venezuela on February 2, 2016 and passed through Hong Kong, China, Shenzhen and Dongguan of Guangdong Province, arrived in Gan County, Ganzhou City, Jiangxi Province on February 5, and was rewarded to Gan County People’s Hospital on February 6, 2016 Department of Infectious Diseases underwent isolation and treatment and was discharged on February 14. The clinical manifestations were fever, dizziness, headache, chills, fatigue, rash, orbital pain, conjunctival congestion, diarrhea and other symptoms; the cases of normal white blood cells and platelets, A slight increase in cell ratio, a slight increase in prothrombin time, a slight decrease in serum albumin, urea nitrogen and uric acid in liver and kidney, and a slight emphysema in left lower lung. The etiological test results showed that urine samples Zika virus nucleic acid existed longer than the serum samples, the incidence of sputum specimens on the 15th day did not detect nucleic acid positive. Conclusions This case is a typical but less symptomatic case of imported Zika virus infection. A survey of returnees with a history of epidemics and fever, rash and other symptoms was also conducted. Serum and urine samples were collected Specimens for testing, is conducive to the early detection of cases, diagnosis and treatment.