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目的：探讨肝素不同给药途径对慢性阻塞性肺疾病急性加重期（AECOPD）患者治疗效果的影响。方法选取2013年2月至2014年8月本院收治的AECOPD患者180例，完全随机分为对照组60例患者给予常规治疗，静脉组60例患者在对照组基础上给予肝素静脉滴注，雾化组60例患者在对照组基础上给予肝素雾化吸入，比较3组患者的血常规与肺功能。结果静脉组和雾化组患者的白细胞（WBC）、红细胞比容（HCT）、血小板计数（PLT）均高于对照组，且雾化组患者的 HCT、PLT 优于静脉组，差异均有统计学意义（均 P＜0.05）；静脉组和雾化组患者的 FEV1、FVC 及RC/TLC指标均高于对照组，差异均有统计学意义（均P＜0.05）。结论肝素不同给药途径对AECOPD患者的治疗效果较好，且雾化给药途径优于静脉滴注。“,”Objective To explore the diferent routes of administration of heparin(AECOPD)treatment in patients with chronic obstructive pulmonary disease with acute exacerbation.Methods Selected in February 2013 to August 2014 AECOPD patients admitted to our hospital 180 patients were randomly divided into a control group of 60 patients treated with conventional therapy group,60 patients were given intravenous heparin infusion in the control group,based on the atomization group to 60 patients in the control group of heparin inhalation,based on the comparison of the three groups of patients with blood and lung function.Results Vein group and the atomization group patients white blood cel(WBC), hematocrit (HCT),platelet count(PLT)were higher than those in the control group,and the atomization group,patients with HCT,PLT is better than that of vein group,the diference was statisticaly significant(P<0.05);vein group and the atomization group in patients with FEV1,FVC and RC/TLC index were higher than the control group,the diference was statisticaly significant(P<0.05).Conclusion Heparin diferent routes of administration for the treatment of patients with AECOPD better and better atomization intravenous route of administration.