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目的了解昌吉地区乙型肝炎疫苗的预防接种对乙型肝炎血清标记物测定结果的影响,为乙型肝炎疫苗的长期接种提供科学依据。方法收集1995年新疆昌吉市某中学1 028名13岁~18岁的在校学生乙型肝炎血清标记物测定结果的资料,2015年本实验室又对该中学1656名曾接种过乙型肝炎疫苗的学生,采用酶联免疫吸附试验(ELISA)进行了乙型肝炎血清标记物测定,用描述流行病学方法对前后2次乙型肝炎检测资料进行统计。结果 2次检测都是以乙型肝炎5项全部阴性百分比最高,分别为58.95%和48.97%。1995年HBsAg阳性率明显高于2015年,差异有统计学意义(P<0.01);2015年HBsAb阳性率明显高于1995年,差异有统计学意义(P<0.01);结论乙型肝炎疫苗有效的预防了乙型肝炎病毒的感染和传播。
Objective To understand the effect of hepatitis B vaccination in Changji city on the determination of hepatitis B serum markers and provide a scientific basis for long-term hepatitis B vaccine inoculation. Methods A total of 1 028 hepatitis B serum markers from 13 to 18 years old were collected from a middle school in Changji, Xinjiang in 1995. According to the data of 1656 hepatitis B vaccine Of students, the use of enzyme-linked immunosorbent assay (ELISA) for the determination of hepatitis B serum markers, using descriptive epidemiological methods to statistics before and after 2 times the hepatitis B test data. The results of the two tests are based on the five most negative percentage of hepatitis B were the highest, respectively, 58.95% and 48.97%. The positive rate of HBsAg in 1995 was significantly higher than that in 2015 (P <0.01); the positive rate of HBsAb in 2015 was significantly higher than that in 1995 (P <0.01); Conclusion Hepatitis B vaccine was effective The prevention of hepatitis B virus infection and transmission.