论文部分内容阅读
肿瘤坏死因子相关凋亡诱导配体(TRAIL)具有选择性细胞毒性,不仅诱导肿瘤细胞凋亡,还诱导肝和脑细胞凋亡,也诱导病毒感染的细胞凋亡,但对机体正常组织无毒性。TRAIL已成为全球新药研究的热点。本文从TRAIL的凋亡通路及其调控、肿瘤细胞对TRAIL抵抗的原因综述TRAIL在难治性疾病治疗中的应用。
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has selective cytotoxicity and induces not only apoptosis of tumor cells but also apoptosis of liver and brain cells as well as apoptosis of virus-infected cells, but not toxicity to normal tissues . TRAIL has become the world’s new drug research hot spots. This article from the TRAIL apoptosis pathway and its regulation, tumor cells TRAIL resistance reasons for the review of TRAIL in the treatment of refractory diseases.