论文部分内容阅读
目的:观察糖胃康对DGP大鼠非酶糖基化终产物(AGEs)的影响。方法:将60只大鼠分为模型组、正常组、对照组、糖胃康高、中、低剂量组,每组10只,模型组、对照组及糖胃康高、中、低剂量组分别给以高热量饮食喂养,正常组大鼠予标准饮食喂养。1月后糖胃康高、中、低剂量组分别以浓度为48 g/kg、24 g/kg、12 g/kg药液10 mL/kg灌胃;模型组,正常组给予等量生理盐水灌胃。对照组每天糖脉康灌胃,10 mL/kg。8周后Brownlee法测定大鼠胃平滑肌AGEs含量。结果:糖胃康各治疗组、模型组和糖脉康对照组大鼠胃平滑肌AGEs含量均明显高于正常组(P<0.01);糖胃康高、中、低剂量组及糖脉康对照组大鼠胃平滑肌AGEs含量均显著低于模型组(P<0.05或P<0.01);糖胃康中、低剂量组与糖脉康对照组组间无显著性差异(P>0.05);糖胃康高剂量组大鼠胃平滑肌AGEs含量明显低于糖胃康中、低剂量组和糖脉康组(P<0.01或P<0.05)。结论:糖胃康有显著抑制DGP大鼠非酶糖基化终产物的作用,且呈一定的量效关系。
Objective: To observe the effects of Tangweikang on non-enzymatic glycation end products (AGEs) in DGP rats. Methods: 60 rats were divided into model group, normal group, control group, Tangweikang high, medium and low dose groups, 10 rats in each group, model group, control group and Tangweikang high, medium and low dose groups Respectively, to high-calorie diet, the normal group of rats fed a standard diet. After 1 month, the model group and the normal group were given the same amount of normal saline (normal saline) at the dosage of 48 g / kg, 24 g / kg and 12 g / kg respectively Gavage. The control group was given Ganmaikang intragastrically every day, 10 mL / kg. Brownlee method was used to measure the content of AGEs in rat gastric smooth muscle after 8 weeks. Results: The content of AGEs in gastric smooth muscle of the rats in the Tangweikang group, the model group and the Tongmaikang control group were significantly higher than those in the normal group (P <0.01) The contents of AGEs in gastric smooth muscle of rats in model group were significantly lower than those in model group (P <0.05 or P <0.01). There was no significant difference between the two groups (P> 0.05) The content of AGEs in gastric smooth muscle of Weigang high dose group was significantly lower than that of Weijikang medium dose, low dose group and CMM group (P <0.01 or P <0.05). CONCLUSION: Tangweikang significantly inhibits the non-enzymatic advanced glycation end products in DGP rats and shows a dose-response relationship.