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目的探讨糖化血红蛋白测定在妊娠糖尿病诊断中的临床意义。方法选择2009年9月至2010年5月在我院就诊的24-28周孕妇120例,年龄21-43岁,平均28岁。其中血糖正常组60例,糖尿病组60例作为研究对象,采用微柱层析法测定空腹静脉血HbAlc。结果妊娠糖尿病组的HbAlc有较高的阳性率为81.7%,而正常妊娠组HbAlc的阳性率为13.3%,两者之间差异具有统计学意义(P<0.05)。结论 HbAlc测定对GDM诊断和筛查有较高的敏感性和特异性,可作为GDM诊断筛查的指标。
Objective To investigate the clinical significance of glycosylated hemoglobin in the diagnosis of gestational diabetes mellitus. Methods From September 2009 to May 2010 in our hospital 24-28 weeks of pregnant women, 120 cases, aged 21-43 years, mean 28 years. Among them, 60 cases of normal blood glucose group and 60 cases of diabetes group were taken as the object of study. HbA1c in fasting venous blood was determined by microcolumn chromatography. Results The positive rate of HbAlc in gestational diabetes mellitus group was 81.7%, while the positive rate of HbAlc in normal pregnancy group was 13.3%. The difference between the two groups was statistically significant (P <0.05). Conclusion The HbAlc assay has a high sensitivity and specificity for the diagnosis and screening of GDM, which can be used as an indicator of GDM diagnosis and screening.