目的探讨一氧化氮、氧化、脂质过氧化与矽肺的关系。方法检测７３例矽肺患者和６０例健康对照者血浆中一氧化氮（ＰＮＯ）、维生素Ｃ（ＰＶＣ）、维生素Ｅ（ＰＶＥ）、β－胡萝卜素（ＰβＣＡＲ）、过氧化脂质（ＰＬＰＯ）及红细胞中超氧化物歧化酶（ＥＳＯＤ）、过氧化氢酶（ＥＣＡＴ）、谷胱甘肽过氧化物酶（ＥＧＳＨＰｘ）、过氧化脂质（ＥＬＰＯ）值。结果与对照组比较，不同病情、不同肺功能状态患者组的ＰＶＣ、ＰＶＥ、ＰβＣＡＲ、ＥＳＯＤ、ＥＣＡＴ、ＥＧＳＨＰｘ平均值均显著降低，ＰＮＯ、ＰＬＰＯ、ＥＬＰＯ平均值均显著升高；各检测值与患病年限均有直线相关；逐步回归表明，病情、肺功能状态与ＰＮＯ、ＰＶＥ、ＥＳＯＤ、ＥＬＰＯ值相关最为密切。结论矽肺患者体内一氧化氮代谢异常，氧化、抗氧化平衡严重失调，氧化和脂质过氧化反应病理性加剧 Objective To investigate the relationship between nitric oxide, oxidation, lipid peroxidation and silicosis. Methods Plasma levels of nitric oxide (PNO), vitamin C (PVC), vitamin E (PVE), β-carotene (PCCAR) in 73 patients with silicosis and 60 healthy controls were detected. , Lipid peroxidation (PLPO) and erythrocyte superoxide dismutase (ESOD), catalase (ECAT), glutathione peroxidase (EGSHPx), had Oxidative lipid (E  LPO) value. Results Compared with the control group, the average values ​​of PVC, PVE, PβCAR, ESOD, ECAT and EGSHPx in patients with different disease and different pulmonary function states were significantly decreased, P NO, PLPO, ELPO average were significantly increased; each test value and the duration of illness have a linear correlation; stepwise regression showed that the disease, pulmonary function status and P  NO, P  VE, E SOD , E  LPO value is most closely related. Conclusion In patients with silicosis, abnormal metabolism of nitric oxide, serious imbalance of oxidation and antioxidation, increased pathological changes of oxidation and lipid peroxidation