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目的:调查武汉地区非淋菌性尿道炎(NGU)患者泌尿生殖道支原体感染及耐药情况,为临床选择治疗支原体感染的抗生素提供参考依据。方法:采用支原体分离、鉴定、计数、药敏试剂盒检测拟诊为NGU患者的解脲脲原体(UU)和人型支原体(MH),并分析药敏试验结果。结果:630例患者中支原体总阳性率38.6%,以UU(30%)感染为主,男性感染率明显高于女性。药敏试验结果显示,UU、MH和UU+MH对药物的敏感性最高者依次为阿奇霉素和美满霉素,UU对氧氟沙星、司帕沙星和罗红霉素耐药性高,MH及UU+MH则对罗红霉素、红霉素和克拉霉素耐药性高。结论:UU成为本地区NGU的主要病原体,治疗本地区泌尿生殖道支原体感染可首选阿奇霉素和美满霉素。
Objective: To investigate the genitourinary tract mycoplasma infection and drug resistance in patients with non-gonococcal urethritis (NGU) in Wuhan and to provide a reference for the clinical selection of antibiotics for mycoplasma infection. Methods: Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) in patients with suspected NGU were detected by Mycoplasma separation, identification, counting and drug sensitivity kit, and drug susceptibility test results were analyzed. Results: The total positive rate of Mycoplasma in the 630 patients was 38.6%. The infection rate was mainly UU (30%). The male infection rate was significantly higher than that of the female. The results of drug sensitivity test showed that the highest drug sensitivity of UU, MH and UU + MH were azithromycin and minocycline, UU had high resistance to ofloxacin, sparfloxacin and roxithromycin, and MH And UU + MH is resistant to roxithromycin, erythromycin and clarithromycin. Conclusion: UU has become the main pathogen of NGU in this area. Azithromycin and minocycline may be the first choice for the treatment of genitourinary tract mycoplasma infection in this area.