【摘 要】
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Dear Editor,rnPrecise editing of specific genomic sites holds great promise in basic research and modern crop breeding,and some cy-tosine base editors (CBEs) have been developed for this purpose (Komor et al.,2016;Zong et al.,2018).Cytosine methylation of
【机 构】
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Key Laboratory of Molecular Biology and Gene Engineering in Jiangxi Province,College of Life Science
论文部分内容阅读
Dear Editor,rnPrecise editing of specific genomic sites holds great promise in basic research and modern crop breeding,and some cy-tosine base editors (CBEs) have been developed for this purpose (Komor et al.,2016;Zong et al.,2018).Cytosine methylation of DNA plays important roles in regulation of chromatin structure and gene expression in animals,plants and fungi (Law and Jacobsen,2010),and it is known that methylation strongly suppresses cytosine deamination cata-lyzed by some APOBEC and AID deaminases in human cells(Nabel et al.,2012).
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