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目的采用三磷酸腺苷法(ATP-TCA)对胰腺癌组织标本进行肿瘤药敏检测,为胰腺癌个体化化疗的选择提供依据。方法21例胰腺癌新鲜标本行肿瘤细胞分离,原代培养后ATP-TCA技术对4种化疗药物进行检测。结果所有标本均顺利完成检测,可评估率为100%。不同胰腺癌不但对同一种化疗药物的敏感度有明显差异(P<0.01),而且对不同药物的敏感程度也具有统计学差异(P<0.01)。结论ATP-TCA可为胰腺癌的临床个体化化疗提供指导作用。
Objective To detect adenosine triphosphate (TAA) in pancreatic cancer tissue by adenosine triphosphate (ATP-TCA) method and provide evidence for the selection of personalized chemotherapy for pancreatic cancer. Methods Twenty-one fresh pancreatic cancer samples were isolated from tumor cells. Four primary chemotherapeutic drugs were detected by ATP-TCA after primary culture. Results All specimens were successfully tested, assessable rate was 100%. Different pancreatic cancer not only had significant difference (P <0.01) but also different sensitivity (P <0.01) to different chemotherapeutic drugs. Conclusion ATP-TCA can provide a guideline for clinical individualized chemotherapy of pancreatic cancer.