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目的：亚硝胺是四大食品污染物之一，大量流行病学资料显示人类的食管癌、肝癌和胃癌等与之有关，其致癌机理，尚无成熟看法，有人提出可能与自由基反应有关，为探讨亚硝胺的致癌机制及与自由基的关系。方法：本研究用不同剂量的二甲基亚硝胺观察其对鼠体脂质过氧化反应的影响。结果：二甲基亚硝胺可使大鼠血清和肝肾ＭＤＡ产生增加；血红细胞和肝肾ＳＯＤ活性下降；全血ＧＳＨ－Ｐｘ活性下降。结论：自由基和脂质过氧化反应可能是二甲基亚硝胺及其它亚硝胺致癌的途径之一。
Objective: Nitrosamine is one of the four major food contaminants. A large number of epidemiological data show that human esophageal cancer, liver cancer, and gastric cancer are related to it. The mechanism of carcinogenesis is not yet mature. Some have suggested that it may be related to free radical reactions. To investigate the carcinogenic mechanism of nitrosamines and its relationship with free radicals. Methods: In this study, different doses of dimethylnitrosamine were used to observe the effect of lipid peroxidation on rats. RESULTS: Dimethylnitrosamine could increase the production of MDA in rat serum, liver and kidney; the activity of SOD in red blood cells and liver and kidney decreased, and the activity of GSH-Px in whole blood decreased. CONCLUSION: Free radicals and lipid peroxidation may be one of the pathways of carcinogenesis induced by dimethylnitrosamines and other nitrosamines.