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目的:研究汉族冠心病(CAD)患者每日应用阿司匹林100mg的抗血小板聚集的效果,指导临床合理应用抗血栓药物。方法:对于入选的CAD患者,在综合治疗基础上每日应用阿司匹林100mg,测定用药7天后血小板聚集力和血栓烷素(TXB2)的含量;测定60例正常对照组的相应指标作为基础值,之后综合判断阿司匹林的抗血小板聚集的效果;此外观察出血性并发症的发生情况。结果:入选的178例CAD患者,68例有心肌梗死病史,110例为不稳定型心绞痛患者。用药7天后,与正常对照组比较,血小板聚集的抑制程度均大于80％;TXB2含量明显降低。未见出血性并发症的发生。结论:汉族CAD患者每日应用阿司匹林100mg可以达到有效的抗血小板聚集的效应。
Objective: To study the anti-platelet aggregation effect of daily aspirin 100mg in patients with coronary heart disease (CAD) in Han nationality and to guide the clinical rational use of antithrombotic drugs. Methods: For selected CAD patients, 100 mg of aspirin was daily applied on the basis of comprehensive treatment. The platelet aggregation and thromboxane (TXB2) content were measured after 7 days of treatment. The corresponding indexes of 60 normal controls were taken as the baseline values. Comprehensive judgments aspirin anti-platelet aggregation effect; In addition to observe the occurrence of bloody complications. Results: Of the 178 CAD patients selected, 68 had a history of myocardial infarction and 110 had unstable angina. After 7 days of treatment, compared with the normal control group, the degree of inhibition of platelet aggregation was more than 80%; TXB2 content was significantly reduced. No bleeding complications occurred. CONCLUSIONS: Aspirin 100 mg can be administered daily to patients with CAD in Han nationality to achieve an effective anti-platelet aggregation effect.