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目的 :探讨血管紧张素 、醛固酮、心房肽在调节机体体液中的作用。方法 :使大鼠体内的钠急剧缺乏 ,用放射免疫分析法 ,对大鼠血浆中血管紧张素 、醛固酮、心房肽浓度进行测定。并观测大鼠饮盐水量的变化。结果 :钠急剧缺乏 ,使大鼠血浆中血管紧张素 、醛固酮浓度显著升高 ,心房肽浓度显著下降。同时激起大鼠的饮盐水行为。大鼠经 3次钠缺乏恢复正常生活 5d时 ,对血管紧张素 、醛固酮的分泌量没有影响 ,而使心房肽的分泌受到抑制。结论 :钠摄入量不同 ,影响体内某些激素的分泌量 ,使机体对水、电解质、血压和血量的调节发生变化 ,这些变化对研究心脑血管系统疾病的预防、发生、治疗有重要意义
Objective: To investigate the role of angiotensin, aldosterone and atrial natriuretic peptide in the regulation of body fluids. Methods: Rats in the rapid lack of sodium, radioimmunoassay, plasma concentrations of angiotensin, aldosterone, atrial natriuretic peptide were determined. And observe the changes of rats drinking salt water. Results: Acute lack of sodium significantly increased the concentration of angiotensin and aldosterone in plasma of rats, and the concentration of atrial natriuretic peptide decreased significantly. At the same time stimulate the rat’s salt water behavior. Rat after 3 sodium deficiency to normal life 5d, the angiotensin, aldosterone secretion had no effect, leaving the secretion of atrial natriuretic peptide was inhibited. CONCLUSIONS: Different intake of sodium affects the secretion of certain hormones in the body and changes the regulation of water, electrolyte, blood pressure and blood volume. These changes are important for the prevention, treatment and development of cardiovascular and cerebrovascular diseases significance