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目的:观察和比较国产盐酸阿扎司琼与进口盐酸昂丹司琼预防化疗所致恶心呕吐的临床疗效和不良反应。方法:43例患者随机分为试验组和对照组,试验组使用国产盐酸阿扎司琼,对照组使用进口盐酸昂丹司琼。结果:试验组和对照组恶心状况差异无显著性( P>0 .0 5 ) ,试验组和对照组止吐的有效率分别为90 .9%和85 .7% ,试验组有效率高于对照组,但差异无显著性( P>0 .0 5 )。结论:国产盐酸阿扎司琼预防化疗所致恶心呕吐有效、安全、经济,值得临床推广。
OBJECTIVE: To observe and compare the clinical efficacy and adverse reactions of domestic-made azasetron and imported ondansetron in preventing chemotherapy-induced nausea and vomiting. Methods: Forty-three patients were randomized into two groups: experimental group and control group. The patients in trial group were given domestic atazantion hydrochloride, while the control group was ondansetron hydrochloride. Results: There was no significant difference in nausea between experimental group and control group (P> 0.05). The effective rates of antiemetic were 90.9% and 85.7% in experimental group and control group respectively. The effective rate of experimental group and control group were higher than Control group, but the difference was not significant (P> 0.05). Conclusion: It is effective, safe and economical to prevent and treat nausea and vomiting caused by domestic homemade asarizon hydrochloride in clinic.