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自从五十年代氯丙嗪问世以来,对于抗精神病药物的研制、药物作用机理、精神病病理机制的探索,起了巨大的推动和促进作用。在受体分析方法出现之前,临床精神行为药理研究,已为抗精神病药物的多巴胺受体阻断假说提供了间接证据,明确了精神分裂症和脑内多巴胺神经系统活动异常的关系。1974年,高放射活性的~3H-配体合成和放射受体分析法的发展,使脑内多巴胺受体的直接研究成为可能,并取得重要进展。这些研究主要集中在如下几个方面:脑内多巴胺受体实体的研究及其细胞学定位;脑内多巴胺神经通路系统探索;精神疾患和脑内多巴胺受体变化的关系;神经阻断剂对多巴胺受体
Since the advent of chlorpromazine in the 1950s, it has played a significant role in promoting the development of antipsychotics, the mechanism of drug action and the pathological mechanism of psychosis. Prior to the advent of receptor analysis, clinical psychobehavioral pharmacological studies have provided indirect evidence for the hypothesis of blockade of dopamine receptors for antipsychotic agents, identifying the relationship between schizophrenia and abnormal dopamine neurological activity in the brain. In 1974, the development of highly radioactive 3H-ligand synthesis and radioreceptor assays made direct studies of dopamine receptors in the brain possible and made important advances. These studies mainly focus on the following aspects: brain dopamine receptor entity research and cytological localization; brain dopamine neural pathway system; mental disorders and brain dopamine receptor changes; nerve blockers of dopamine Receptor