Mathematical model of solute [C] distribution in twin-roll strip casting process has been setup successfully with Calcosoft for the first time. Simulation result shows that in the center of the molten steel pool between the two rolls there is a vortex flow, which is a solute enriched area. But the highest solute concentration position is at the solidification front of the columnar grain zone near the cooling roll surface. Another solute enriched position is in the back flow above the nip point. Combined with the formation mechanism of microstruoture in final as cast strip, analysis shows that solute enriched area is in the transitional area between columnar and equiaxed grain zone.