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目的对比探讨应用美罗培南不同输注方案对于呼吸机相关性肺炎(VAP)的临床治疗效果。方法 98例呼吸机相关性肺炎患者,采用随机数字表法将其分为观察组和对照组,各49例。对照组患者应用间断输注美罗培南的方式;观察组则采取持续静脉输注的方式。比较两组患者的临床效果。结果观察组总有效率为87.76%,高于对照组的69.39%,差异具有统计学意义(P<0.05)。观察组患者机械通气时间、平均医疗费用、治疗疗程均优于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率为12.24%,与对照组的10.20%比较差异无统计学意义(P>0.05)。结论应用持续静脉输注美罗培南的方式对呼吸机相关性肺炎患者进行干预具有安全可靠的疗效,可显著改善患者病情,减少患者的医疗费用,具有较高的临床应用价值。
Objective To compare the clinical effects of different infusion schemes of Meropenem on ventilator-associated pneumonia (VAP). Methods A total of 98 patients with ventilator - associated pneumonia were divided into observation group and control group by random number table method, each with 49 cases in each group. Patients in the control group were given intermittent infusion of meropenem, while patients in the observation group were given continuous infusion of intravenous infusion. The clinical effects of the two groups were compared. Results The total effective rate in observation group was 87.76%, which was higher than 69.39% in control group, the difference was statistically significant (P <0.05). The observation group patients with mechanical ventilation time, the average medical costs, treatment courses were better than the control group, the difference was statistically significant (P <0.05); observation group adverse reaction rate was 12.24%, compared with the control group 10.20% no statistical difference Significance (P> 0.05). Conclusions The continuous intravenous infusion of Meropenem has a safe and reliable therapeutic effect on patients with ventilator-associated pneumonia, which can significantly improve the patient’s condition, reduce the patient’s medical costs, and has a high clinical value.