论文部分内容阅读
目的:探讨FHL2基因在大肠癌中的表达及其临床意义。方法:用免疫组织化学方法检测35例大肠癌组织、15例大肠息肉组织和15例正常结肠黏膜组织中FHL2蛋白的表达情况,并分析其与相关临床病理因素的关系。结果:FHL2蛋白表达阳性率在大肠癌组织中显著高于正常大肠黏膜组织和大肠息肉组织。结论:FHL2蛋白在大肠癌组织中高度表达,但表达程度与癌症病理分级无明显相关性。
Objective: To investigate the expression of FHL2 gene in colorectal cancer and its clinical significance. Methods: The expressions of FHL2 protein in 35 cases of colorectal carcinoma, 15 cases of colorectal polyps and 15 cases of normal colonic mucosa were detected by immunohistochemistry. The relationship between FHL2 protein and clinicopathological factors was analyzed. Results: The positive rate of FHL2 protein in colorectal cancer was significantly higher than that in normal colorectal mucosa and colorectal polyps. Conclusion: FHL2 protein is highly expressed in colorectal cancer tissues, but its expression level has no significant correlation with the pathological grade of cancer.