自从20世纪70年代人们发现哺乳动物脑中存在有阿片受体以来,它们的药理学特征已得到充分阐述,这使对阿片碱类药物的药物作用原理的认识进入到分子水平。但其分子生物学特性研究却未能取得很大进展,这主要是由于阿片受体很难在保持配体结合活性的条件下被纯化。尽管如此,阿片受体的纯化和分子生物学的研究仍取得了实质性进 Since the discovery of opioid receptors in mammalian brains in the 1970s, their pharmacological properties have been well documented, raising the awareness of the principles of opioid drug action to molecular levels. However, great progress has not been made in the study of their molecular biological properties, mainly due to the fact that opioid receptors are very difficult to be purified while maintaining the ligand-binding activity. In spite of this, the research on opioid receptor purification and molecular biology has made substantial progress