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目的高血压并发脑梗死患者同型半胱氨酸的观察。方法采用前瞻性对照研究观察项目;同型半胱氨酸测定,方法采用循环酶法,试剂用浙江康特生物科技有限公司。仪器用奥林巴斯5421仪(全自动生化分析仪)。2012年1～7月住本院神经内科,100例高血压并发脑梗死患者同型半胱氨酸的观察。脑梗死标准按照1995年第四届全国脑血管病诊断标准,全部经头颅CT和MRI确诊。结果①高同型半胱氨酸的高血压脑梗死组与低同型半胱氨酸的高血压脑梗死的同型半胱氨酸对比,差异有统计学意义(P<0.05)。②高同型半胱氨酸的高血压脑梗死组与低同型半胱氨酸的高血压脑梗死组的收缩血压对比,差异有统计学意义(P<0.05)。③高同型半胱氨酸的高血压脑梗死组与低同型半胱氨酸的高血压脑梗死组的舒张血压对比,差异有统计学意义(P>0.05)。结论高血压和高同型半胱氨酸(H型高血压)在导致脑卒中事件具有显著的协同作用。因此,同时控制血压和同型半胱氨酸水平有可能进一步地降低脑卒中事件发生风险。
Objective To observe the homocysteine in hypertensive patients with cerebral infarction. Methods The prospective controlled study was used to observe the project. The homocysteine was determined by the method of circulating enzyme and the reagent Zhejiang Kangte Biological Technology Co., Ltd. Instrument Olympus 5421 instrument (automatic biochemical analyzer). From January to July 2012, we observed the homocysteine in 100 patients with hypertensive cerebral infarction in our department of neurology. The standard of cerebral infarction was diagnosed according to the diagnostic criteria of the fourth national cerebrovascular disease in 1995 and all by CT and MRI. Results ① The homocysteine level in hypertensive cerebral infarction patients with homocysteine was significantly lower than that with hypo-homocysteine (P <0.05). (2) There was significant difference in systolic blood pressure between hyperhomocysteine-induced hypertensive cerebral infarction group and hypo-homocysteine-induced hypertensive cerebral infarction group (P <0.05). (3) The diastolic blood pressure of hypertensive cerebral infarction group with high homocysteine and hypertensive cerebral infarction with low homocysteine had statistical significance (P> 0.05). Conclusions Hypertension and hyperhomocysteine (Hypertension) have a significant synergistic effect on stroke. Therefore, the simultaneous control of blood pressure and homocysteine levels may further reduce the risk of stroke.