This paper proposes a novel algorithm, which can be used to model and analyze mesh tree hybrid power/ground distribution networks with multiple voltage supply in time domain. Not only this algorithm enhances common method’s ability on analysis of power/ground network with irregular topology, but also very high accuracy it keeps. The accuracy and stability of this algorithm is proved using strict math method in this paper. Also, the usage of both precondition technique based on Incomplete Choleskey Decomposition and fast variable elimination technique has improved the algorithm’s efficiency a lot. Experimental results show that it can finish the analysis of power/ground network with enormous size within very short time. Also, this algorithm can be applied to analyze the clock network, bus network, and signal network without buffer under high working frequency because of the independence of the topology.