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近年来 ,细菌耐药性的问题日益成为全球医药界共同关注的热点 ,细菌对抗生素的耐药机制包括4个方面 :①产生各种灭活酶使抗生素失效 ,如 β 内酰胺酶、氨基糖苷类的钝化酶。②与抗生素结合靶位改变 ,使抗生素与细菌的亲和力下降 ,从而使抗生素失活或活性下降。③细胞膜通透性的
In recent years, the issue of bacterial resistance has increasingly become a hot spot of common concern in the global medical community. The mechanism of bacterial resistance to antibiotics includes four aspects: ① producing various inactivated enzymes to disable antibiotics such as β-lactamase, aminoglycoside Class of passive enzyme. ② target combination with antibiotics to change, so that the affinity of antibiotics and bacteria decreased, so that antibiotics inactivated or decreased activity. ③ cell membrane permeability