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目的观察氨基末端脑钠肽前体(N-terminal pro brain natriuretic peptide,NT-pro BNP)对老年慢性心力衰竭(心衰)患者的诊断价值,观察其对红细胞参数和血小板参数的影响,并探讨其临床意义。方法选择2013年1月—2014年12月收治的150例老年心衰患者作为研究对象,根据患者NT-pro BNP水平分为BNP增高组55例及BNP正常组95例。记录并比较两组红细胞参数(HB、RBC、RDW、HCT)和血小板参数(MPV、PDW、P-LCR)。计量资料采用t检验,P<0.05为差异有统计学意义。结果 BNP正常组HB、RBC、RDW、HCT水平分别为(135.18±17.51)g/L、(4.52±0.57)×1012/L、(13.9±1.6)%、(40.20±7.25)%,与BNP增高组的(120.92±18.52)g/L、(3.82±0.68)×1012/L、(14.9±1.7)%、(36.63±6.26)%比较差异均有统计学意义(均P<0.05)。BNP正常组MPV、PDW水平分别为(14.7±1.2)、(16.2±1.8)fl,与BNP增高组的(18.8±2.1)、(18.0±1.5)fl比较差异均有统计学意义(均P<0.05)。结论 RDW、PDW、MPV水平可作为评价心衰患者心功能的临床指标,心衰时血小板活化,与心衰患者易发生栓塞性疾病密切相关。
Objective To investigate the diagnostic value of N-terminal pro brain natriuretic peptide (NT-pro BNP) in senile patients with chronic heart failure (CHF) and to observe its effect on erythrocyte parameters and platelet parameters Its clinical significance. Methods A total of 150 elderly patients with heart failure admitted from January 2013 to December 2014 were enrolled in this study. According to the level of NT-pro BNP, 55 patients with elevated BNP and 95 normal BNP patients were enrolled. Red blood cell parameters (HB, RBC, RDW, HCT) and platelet parameters (MPV, PDW, P-LCR) were recorded and compared. Measurement data using t test, P <0.05 for the difference was statistically significant. Results The levels of HB, RBC, RDW and HCT in the normal BNP group were (135.18 ± 17.51) g / L, (4.52 ± 0.57) × 1012 / L, (13.9 ± 1.6)% and (40.20 ± 7.25) (120.92 ± 18.52) g / L, (3.82 ± 0.68) × 1012 / L, (14.9 ± 1.7)%, (36.63 ± 6.26)%, respectively. There were significant differences between the two groups (all P <0.05). The levels of MPV and PDW in BNP normal group were (14.7 ± 1.2) and (16.2 ± 1.8) fl, respectively, which were significantly different from those in the group with elevated BNP (18.8 ± 2.1 and 18.0 ± 1.5) fl (all P < 0.05). Conclusions The RDW, PDW and MPV levels can be used as clinical indexes to evaluate the cardiac function in patients with heart failure. Platelet activation during heart failure is closely related to the occurrence of embolic diseases in patients with heart failure.