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目的探讨疱疹性口腔炎患儿合用开喉剑喷剂与药物治疗的临床适用性及安全性。方法选取2013年8月至2015年8月沈阳市儿童医院收治的疱疹性口腔炎患儿70例为研究对象,按随机数字表法分为观察组和对照组,每组35例。对照组患儿接受常规药物治疗,观察组患儿在药物治疗的基础上接受开喉剑喷剂治疗,治疗1个疗程后,比较两组治疗的适用性及安全性。结果观察组患儿的治疗总有效率为94.3%,较对照组的74.3%显著提高,差异有统计学意义(P<0.05)。观察组患儿的体温正常时间为(2.1±1.2)d,口腔疱疹消退时间为(5.8±1.3)d,平均住院时间为(6.9±1.5)d,均较对照组显著缩短,差异均有统计学意义(均P<0.05)。两组患儿在治疗期间均未发生严重不良反应。结论合用药物与开喉剑喷剂治疗小儿疱疹性口腔炎疗效显著,安全性高,且有利于患儿症状的早日恢复。
Objective To investigate the clinical applicability and safety of combined open throat sirup and medical treatment in children with herpetic stomatitis. Methods Seventy cases of herpes stomatitis admitted to Children’s Hospital of Shenyang from August 2013 to August 2015 were selected as study objects and divided into observation group and control group according to random number table method, with 35 cases in each group. Children in the control group received routine medical treatment. Children in the observation group were treated with open throat sore spray on the basis of medical treatment. After one course of treatment, the applicability and safety of the two groups were compared. Results The total effective rate in treatment group was 94.3%, which was significantly higher than that in control group (74.3%), the difference was statistically significant (P <0.05). The average body temperature in observation group was (2.1 ± 1.2) d, oral herpes subsidence time was (5.8 ± 1.3) d, and the average length of hospital stay was (6.9 ± 1.5) days, which were significantly shorter than those in control group Significance (both P <0.05). Two groups of children during the treatment did not occur serious adverse reactions. Conclusion Combination of drugs and open throat sword spray treatment of children with herpes stomatitis significant effect, high safety, and is conducive to the early recovery of children’s symptoms.