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目的:观察磷酸肌酸钠治疗新生儿缺氧缺血性心肌损害的疗效。方法:将80例新生儿缺氧缺血性心肌损害患儿随机分为治疗组和对照组各40例。两组均给予常规对症支持治疗,对照组同时给予维生素C 0.5 g加能量合剂静脉滴注,1次/d,10 d为1个疗程,治疗组同时给予磷酸肌酸钠0.5 g/次静脉滴注,1次/d,10 d为1个疗程。观察两组患儿治疗前后症状、体征、心电图改变、心肌酶谱。结果:治疗组的总有效率为87.5%,明显高于对照组67.5%(χ2=4.59,P<0.05)。治疗组与对照组治疗后在循环改善、心律失常消失、心电图恢复、心肌酶谱恢复等方面比较差异有统计学意义(P<0.05)。结论:磷酸肌酸钠治疗新生儿缺氧缺血性心肌损害疗效显著。
Objective: To observe the effect of sodium creatine phosphate in neonatal hypoxic-ischemic myocardial damage. Methods: Eighty neonates with hypoxic ischemic myocardial damage were randomly divided into treatment group and control group, 40 cases each. Both groups were given conventional symptomatic and supportive treatment. In the control group, vitamin C 0.5 g plus energy mixture was also given intravenously once a day for 10 days. The treatment group was treated with 0.5 g sodium phosphate / Note, 1 / d, 10 d for a course of treatment. The symptoms, signs, electrocardiogram changes and myocardial enzymes of the two groups were observed before and after treatment. Results: The total effective rate in the treatment group was 87.5%, which was significantly higher than that in the control group (χ2 = 4.59, P <0.05). After treatment, the improvement of circulation, disappearance of arrhythmia, recovery of electrocardiogram and recovery of myocardial enzymes in treatment group and control group were statistically significant (P <0.05). Conclusion: Sodium phosphate creatine is effective in treating neonatal hypoxic-ischemic myocardial damage.