论文部分内容阅读
目的 建立诊断肺气肿及阻塞性通气障碍的CT肺功能参数阈值。方法 对照组20 例,阻塞性通气障碍组37例(包括肺气肿23例、哮喘6例、不明原因8例)。肺功能检查和定量CT检查均在1周内完成。利用CT肺功能定量分析软件分析图像数据并得出相应的肺功能参数值,包括肺平均CT密度值、像素指数(PI-700~-800,PI-800~-900, PI-910,PI-950),比较各组参数值的差异。结果 阻塞性通气障碍组最大吸气末CT值为(-834.68±29.54) Hu,最大呼气末CT值为(-770.48±55.07) Hu,与正常组均存在差异。吸气末及呼气末PI-910in、PI-910ex与PFT各参数(FEV1,FEV1/FVC,DLco%)的相关性分别较其他像素指数要好。PI-910in>15%考虑患有阻塞性通气障碍, PI-950in、PI-910ex的分布代表阻塞性通气功能障碍的范围,PI-950ex代表肺气肿的分布范围。结论 建立CT肺功能成像参数阈值可为临床诊断相关疾病提供客观依据。
Objective To establish a threshold value of CT pulmonary function parameters for the diagnosis of emphysema and obstructive ventilatory disorders. Methods 20 cases in control group and 37 cases in obstructive ventilatory disorder group (including 23 cases of emphysema, 6 cases of asthma and 8 cases of unexplained cause). Pulmonary function tests and quantitative CT examination were completed within 1 week. The CT data of pulmonary function were analyzed and the corresponding values of pulmonary function parameters were obtained, including average pulmonary CT density, pixel index (PI-700 ~ -800, PI-800 ~ -900, PI- 910, PI- 950) to compare the difference between the parameters of each group. Results The maximal end-inspiratory CT value of the patients with obstructive ventilatory disorder was (-834.68 ± 29.54) Hu and the maximum end-tidal CT value was (-770.48 ± 55.07) Hu, which was different from the normal group. The end-inspiratory and end-expiratory PI-910in, PI-910ex and PFT parameters (FEV1, FEV1 / FVC, DLco%) correlation were better than other pixel index. PI-910in> 15% Considering obstructive ventilatory disorders, the distribution of PI-950in, PI-910ex represents the range of obstructive ventilatory dysfunction and PI-950ex represents the distribution of emphysema. Conclusion Establishing the threshold value of CT pulmonary function imaging can provide an objective basis for the clinical diagnosis of related diseases.