一.从左旋四氢巴马汀到左旋千金藤啶碱左旋四氢巴马汀(l-tetrahydropalmatine,l-THP)和左旋千金藤啶碱(l-Stepholidine,l-SPD)同属于四氢原小檗碱同类物(tetrahydro-proto-berberines,THPB),有相同的化学结构母核(图1)。l-SPD在C_2和C_(10)位由OH基取代OCH_3基,使药理作用出现不少新特点,经临床试用,可望成为有价值的第二代新药。l-SPD的发现与作者近年来研究ι-THP One from l-tetrahydropalmatine to levamisole alkaloids l-tetrahydropalmatine (l-THP) and levamisolelline base (l-SPD) belong to the four hydrogen The tetrahydro-proto-berberines (THPB) have the same chemical structure of the mother nucleus (Figure 1). l-SPD substituted OH group at C_2 and C_ (10) to OCH_3 group, which made many pharmacological effects appear new features. After clinical trials, l-SPD is expected to be a valuable second-generation new drug. l-SPD discovery and author in recent years, study ι-THP