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目的研究肺癌细胞中性染色体拷贝数的异常。方法取新鲜的肺癌手术标本作印片，利用双色荧光原位杂交（ｄｕａｌ－ｃｏｌｏｒＦＩＳＨ）技术对１６例肺癌印片标本（其中男性病例１２例，女性病例４例）中Ｘ染色体和Ｙ染色体数目进行检测。结果发现１２／１６（７５％）的标本中有Ｘ染色体数目增多，其中女性患者３例，男性患者９例；在１２例男性患者中，有１例发生Ｙ染色体数目增多，有５例（４１．７％）发生Ｙ染色体数目减少。总计出现性染色体数目异常的病例为１３例，占１６例的８１．２５％。结论Ｘ染色体数目增多在肺癌中发生的频率很高，其意义值得进一步研究。
Objective To study the abnormality of sex chromosome copy number in lung cancer cells. Methods Fresh lung cancer specimens were used for printing. The number of X and Y chromosomes in 16 lung cancer specimens (including 12 male and 4 female) was measured by dual-color fluorescence in situ hybridization (FISH). Testing. The results showed that 12/16 (75%) specimens had an increased number of X chromosomes, including 3 females and 9 males; in 12 males, 1 had an increase in the number of Y chromosomes and 5 (41). .7%) The number of Y chromosomes decreased. The total number of cases with abnormal sex chromosomes was 13 cases, accounting for 81.25% of 16 cases. Conclusion The increased frequency of X chromosomes is high in lung cancer and its significance is worthy of further study.