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目的 探讨呼气末定量CT对早期小气道病变的诊断价值。材料与方法 病例组及对照组在 10 %肺活量 (VC)和 90 %VC呼吸水平下于隆突层、隆突上、下各 5cm处行HRCT扫描。用定量指标分析结果及与临床肺功能的相关性。结果 病例组在呼气末图像上发现有空气残留 ,而吸气末正常。 10 %VC时病例组与对照组定量指标有极显著性差异 ,90 %VC时无显著性差异。定量指标与肺功能指标相关性良好。结论 呼气末定量CT是早期小气道病变的灵敏、准确、客观、可重复性好的检查方法 ,是临床肺功能检查的补充。
Objective To investigate the value of quantitative end expiratory CT in the diagnosis of early small airway disease. MATERIALS AND METHODS The HRCT scan was performed at 5 cm above and below the carina in the case group and the control group at 10% spirometry (VC) and 90% VC respiration, respectively. Quantitative analysis of the results and the correlation with clinical lung function. Results In the end-tidal images, the patient group found that there was residual air, while the end-inspiratory was normal. There was a significant difference of quantitative indexes between case group and control group at 10% VC, but there was no significant difference at 90% VC. Quantitative indicators and pulmonary function indicators related well. Conclusion End-tidal quantitative CT is a sensitive, accurate, objective and reproducible method for early diagnosis of small airway disease. It is a supplement to clinical pulmonary function tests.