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目的观察充血性心力衰竭患者应用神经内分泌调节剂治疗的临床疗效。方法选择各种心脏疾病所致的充血性心力衰竭患者96例随机分为治疗组52例及对照组44例,对照组仅治疗原发病及给予强心、利尿、对症处理,治疗组在常规治疗原发病及强心、利尿、对症的基础上依病情给予β受体阻滞剂、ACEI、地尔硫卓、醛固酮及辅予5%葡萄糖液+黄芪30ml静脉滴注射10天等治疗,记录观察治疗前后心功能分级变化、左室舒张末期内径、左室射血分数、心胸比率。结果治疗组对各种心脏病导致的心衰均有效,尤其对高血压病和扩张型心肌病引起的心衰效果更显著,对心衰病人的心功能、左室舒张末期内径、左室射血分数、心胸比率均有很大的改善,与对照组比较有明显差异。结论充血性心力衰竭患者在治疗原发病及强心、利尿的基础上规范使用神经内分泌调节剂治疗,对保护心肌、逆转心室重塑、改善心功能、延长生存率有一定疗效。
Objective To observe the clinical efficacy of neuroendocrine regulators in patients with congestive heart failure. Methods Ninety-six patients with congestive heart failure caused by various heart diseases were randomly divided into treatment group (n = 52) and control group (n = 44). Control group was treated only with primary disease and given cardiac, diuretic and symptomatic treatment. Treatment of primary disease and cardiac, diuretic, symptomatic on the basis of the disease given β-blockers, ACEI, diltiazem, aldosterone and supplemented with 5% glucose solution + 30ml intravenous infusion of astragalus 10 days and other treatment records were observed and treated Before and after changes in cardiac function, left ventricular end-diastolic diameter, left ventricular ejection fraction, cardiothoracic ratio. Results The treatment group was effective in treating all kinds of heart failure caused by heart disease, especially for the heart failure caused by hypertension and dilated cardiomyopathy. The heart function, left ventricular end-diastolic diameter, Blood scores, cardiothoracic rate have greatly improved, compared with the control group were significantly different. Conclusions The treatment of patients with congestive heart failure on the basis of the treatment of primary disease and cardiac and diuretic normotensitization using neuroendocrine regulators has a certain curative effect on protecting myocardium, reversing ventricular remodeling, improving cardiac function and prolonging survival.