近来研究发现,一类被称为髓源性抑制细胞(Myeloid-derived suppressor cells,MDSCs)的细胞群,参与了肿瘤的免疫逃逸、免疫耐受、免疫抑制等病理过程,促进肿瘤的发生和生长。这群细胞主要分布在血液、脾、淋巴结、骨髓及肿瘤微环境等部位,通过复杂的分子途径,对机体的抗肿瘤免疫起抑制作用。本文就MDSCs在这方面作用的研究进展作一综述。 Recently, it has been found that a group of cell populations called Myeloid-derived suppressor cells (MDSCs) are involved in the pathological processes such as immune escape, immune tolerance and immunosuppression of tumors, and promote tumorigenesis and growth . These cells are mainly distributed in the blood, spleen, lymph nodes, bone marrow and tumor microenvironment and other parts, through the complex molecular pathways, the body’s anti-tumor immunity has an inhibitory effect. This article reviews the research progress of MDSCs in this aspect.