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目的探讨不同剂量丁苯酞对急性脑梗死患者血管内皮功能及肝肾功能的影响。方法选取郑州市郑煤集团总医院2014年1月—2015年1月收治的90例急性脑梗死患者,随机分成观察组和对照组,各45例。两组均给予常规治疗,对照组应用丁苯酞剂量为100ml/d,观察组应用丁苯酞剂量为200ml/d,观察两组患者血管内皮功能(内皮素、血栓素A2、血管内皮细胞生长因子及一氧化氮)以及肝肾功能(尿蛋白、尿红细胞、丙氨酸氨基转移酶及天冬氨酸氨基转移酶)。结果观察组内皮素、血栓素A2以及血管内皮细胞生长因子水平高于对照组,一氧化氮水平低于对照组,差异有统计学意义(P<0.05)。两组患者尿蛋白、尿红细胞、丙氨酸氨基转移酶、天冬氨酸氨基转移酶水平比较,差异无统计学意义(P>0.05)。结论大剂量丁苯酞治疗急性脑梗死有助于进一步提高患者的血管内皮功能,可有效缓解其临床症状,且不对患者肝肾功能造成损害。
Objective To investigate the effects of different doses of butylphthalide on vascular endothelial function and liver and renal function in patients with acute cerebral infarction. Methods Ninety patients with acute cerebral infarction who were admitted to Zhengzhou General Hospital of Coal Industry from January 2014 to January 2015 were randomly divided into observation group and control group, with 45 cases in each group. The two groups were given conventional treatment, the control group, the dosage of butylphthalide 100ml / d, the observation group, the dosage of butylphthalide 200ml / d, the two groups were observed vascular endothelial function (endothelin, thromboxane A2, vascular endothelial cell growth Factor and nitric oxide) and liver and kidney function (urine protein, urinary erythrocytes, alanine aminotransferase and aspartate aminotransferase). Results The levels of endothelin, thromboxane A2 and vascular endothelial growth factor in the observation group were higher than those in the control group, and the level of nitric oxide was lower in the observation group than in the control group (P <0.05). Urine protein, urinary red blood cells, alanine aminotransferase, aspartate aminotransferase levels in two groups of patients, the difference was not statistically significant (P> 0.05). Conclusion High-dose butylphthalide treatment of acute cerebral infarction helps to further improve the endothelial function of patients, which can effectively relieve the clinical symptoms, and does not cause liver and kidney damage in patients.