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目的探讨血小板抗体检测与血小板配型输注的临床应用价值。方法 130例需行血小板输注治疗的患者,根据其是否有输血史分成有输血史组65例和无输血史组65例。经固相凝集法检验血小板抗体,结果显示血小板抗体阳性者40例,26例采取配合行血小板输注治疗作为观察组,14例予以随机血小板输注治疗作为对照组,比较两组血小板输注治疗有效率。结果有输血史组患者抗体阳性率为46.2%高于无输血史15.4%;观察组血小板输注有效率88.5%高于对照组35.7%,差异均具有统计学意义(P<0.05)。结论行异体输血治疗者容易出现血小板抗体,但对血小板抗体阳性者实施血小板配型输注治疗,则可显著提升血小板输注治疗有效性。
Objective To investigate the clinical value of detecting platelet antibodies and platelet transfusion. Methods One hundred and thirty patients undergoing platelet transfusion were divided into 65 cases of transfusion history group and 65 cases of non-transfusion history group based on whether they had transfusion history or not. Platelet antibody was detected by solid-phase agglutination. The results showed that platelet antibody was positive in 40 cases, 26 cases were treated with platelet transfusion as observation group and 14 cases were treated with random platelet transfusion as control group. The platelet transfusion therapy Efficient. Results The positive rate of antibody in blood transfusion group was 46.2% higher than 15.4% without blood transfusion; the effective rate of platelet transfusion in observation group was 88.5% higher than that in control group (35.7%), the difference was statistically significant (P <0.05). Conclusion Allogeneic blood transfusion therapy is prone to platelet antibodies, but platelet antibody infusion therapy for platelet antibody positive patients can significantly improve the effectiveness of platelet transfusion therapy.