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In this paper, the molecular and crystal structures of the K3·5H2O(TTHA=triethylenetetraminehexaacetic acid)are given. The crystal data are as follows: monoclinic system, P21/c space group, a=1.0290(9)nm, b=1.2466(11)nm, c=2.279(2)nm, β=91.322(16)°, V=2.923(5)nm3, Z=4, M=860.67, Dc=1.956gcm-3, μ=3.217mm-1, F(000)=1720. The final R1 and wR2 are 0.0395 and 0.0796 for 5145 [I >2.0σ(I)] unique reflections and 0.0546 and 0.0833 for all 11567 reflections, respectively. In the title complex, the anion 3- has a nine coordination structure with distorted tricapped trigonal prism. A TTHA having four N atoms of amido groups and six O atoms of carboxylic groups acts as a enneadentate ligand with four N atoms and five O atoms. In addition, there is a free non coordinated carboxyl group ( CH2COO-) in the complex anion 3-. The free carboxyl group could be embellished by some biological molecules which have selectivity and affinity to tumor cell. Then the 166HoⅢ TTHA complex may become radioactive anti tumor drug having targeting function.
In this paper, the molecular and crystal structures of the K3 · 5H2O (TTHA = triethylenetetraminehexaacetic acid) are given. The crystal data are as follows: monoclinic system, P21 / c space group, a = 1.0290 (9) nm, b = 1.2466 Β = 91.322 (16) °, V = 2.923 (5) nm3, Z = 4, M = 860.67, Dc = 1.956 gcm-3 and μ = 3.217 mm -1 , F (000) = 1720. The final R1 and wR2 are 0.0395 and 0.0796 for 5145 [I> 2.0σ (I)] unique reflections and 0.0546 and 0.0833 for all 11567 reflections, respectively. In the title complex, the anion 3- has a nine coordination structure with distorted tricapped trigonal prism. A TTHA having four N atoms of amido groups and six O atoms of carboxylic groups acts as an enneadentate ligand with four N atoms and five O atoms. carboxyl group (CH2COO-) in the complex anion 3-. The free carboxyl group could be embellished by some biological molecules which have selectivity and affinity to tumor cell. Then the 166HoⅢ TTHA complex may become rad ioactive anti tumor drug having targeting function.