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既往对冠心病的流行病和介入性研究多集中于男性患者,虽然一般认为这些资料也适用于女性,但无支持该论点的证据。 1972至1976年间英国Renfrew地区和Paisley地区的15399例成人(其中女性8262例)入选,分别占这两个地区45~64岁城市居民的79%和78%。在15年随访期间确定因冠心病死亡的女性为490例,男性878例。与男性相比,女性冠心病患者社会地位较低,肥胖者较多,胆固醇较高,吸烟者较少而血压相仿。胆固醇五分位值女性分别是5.5、6.1、6.6和7.2mmol/L,男性分别是5.0、5.6、6.0和6.6mmol/L;舒张压五分位值女性分别为
Past epidemiological and interventional studies of coronary heart disease are mostly concentrated on male patients. Although these data are generally considered suitable for women, there is no evidence to support this argument. Between 1972 and 1976, 15,399 adults (including 8262 females) were enrolled in the Renfrew and Paisley districts of the United Kingdom, which accounted for 79% and 78% of urban residents aged between 45 and 64 in the two regions. During the 15-year follow-up period, 490 women died of coronary heart disease and 878 men were identified. Compared with men, women with coronary heart disease have lower social status, more obese people, higher cholesterol, fewer smokers and similar blood pressure. The quintiles for cholesterol were 5.5, 6.1, 6.6, and 7.2 mmol/L for women, 5.0, 5.6, 6.0, and 6.6 mmol/L for men, and for women with diastolic quintiles respectively.