A new meta-heuristic method is proposed to enhance current meta-heuristic methods for global optimization and test scheduling for three-dimensional(3D) stacked system-on-chip(SoC) by hybridizing grey wolf optimization with differential evolution(HGWO). Because basic grey wolf optimization(GWO) is easy to fall into stagnation when it carries out the operation of attacking prey, and differential evolution(DE) is integrated into GWO to update the previous best position of grey wolf Alpha, Beta and Delta, in order to force GWO to jump out of the stagnation with DE’s strong searching ability. The proposed algorithm can accelerate the convergence speed of GWO and improve its performance.Twenty-three well-known benchmark functions and an NP hard problem of test scheduling for 3D SoC are employed to verify the performance of the proposed algorithm. Experimental results show the superior performance of the proposed algorithm for exploiting the optimum and it has advantages in terms of exploration. A new meta-heuristic method is proposed to enhance current meta-heuristic methods for global optimization and test scheduling for three-dimensional (3D) stacked system-on-chip (SoC) by hybridizing gray wolf optimization with differential evolution basic gray wolf optimization (GWO) is easy to fall into stagnation when it carries out the operation of attacking prey, and differential evolution (DE) is integrated into GWO to update the previous best position of gray wolf Alpha, Beta and Delta, in order to force GWO to jump out of the stagnation with DE’s strong searching ability. The proposed algorithm can accelerate the convergence speed of GWO and improve its performance. twenty-three well-known benchmark functions and an NP hard problem of test scheduling for 3D SoC are employed to verify the performance of the proposed algorithm. Experimental results show the superior performance of the proposed algorithm for exploiting the optimum and it has advantages in terms of explorati on.