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目的研究急性脑梗死患者颈动脉粥样斑块程度与血清纤维蛋白原水平之间的关系。方法对85例急性脑梗死住院患者通过颈动脉彩色多普勒超声确定有无颈动脉斑块,根据结果分成斑块组(颈动脉IMT≥1.2mm和/或有颈动脉斑块)63例和无斑块组(颈动脉IMT<1.2mm且无颈动脉斑块)22例,然后根据动脉粥样硬化严重程度分为4组,同时测定血清纤维蛋白原水平,分析斑块组、无斑块组及不同程度斑块组间血清纤维蛋白原水平的差异。结果组间性别、年龄、血脂、血糖比较无显著差异(P>0.05),斑块组血清纤维蛋白原水平明显高于无斑块组,有统计学意义(P<0.05),且随着斑块程度的增加,血清纤维蛋白原呈逐渐上升趋势。结论在急性脑梗死患者颈动脉粥样硬化的发生、发展中,血清纤维蛋白原起着至关重要的作用;且纤维蛋白原与颈动脉粥样硬化病变严重程度呈正相关。
Objective To study the relationship between carotid plaque and serum fibrinogen in patients with acute cerebral infarction. Methods Eighty-five inpatients with acute cerebral infarction were divided into carotid plaques (carotid IMT≥1.2mm and / or carotid plaques) by carotid color Doppler sonography. No plaque group (carotid IMT <1.2mm and no carotid plaques), 22 cases, and then divided into four groups according to the severity of atherosclerosis, serum fibrinogen levels were also analyzed, plaque group, no plaque The difference of serum fibrinogen level between different groups and plaque groups. Results There was no significant difference in sex, age, blood fat and blood glucose among the groups (P> 0.05). The level of serum fibrinogen in the plaque group was significantly higher than that in the plaque group (P <0.05) Increase in the degree of block, serum fibrinogen showed a gradual upward trend. Conclusions Serum fibrinogen plays a crucial role in the development and progression of carotid atherosclerosis in patients with acute cerebral infarction. Fibrinogen is positively correlated with the severity of carotid atherosclerosis.