[Objective]To study anti-inflammatory effects of water extract of the stems and leaves of Platycodon grandiflorum.[Methods]Observed anti-inflammatory effects of water extract of the stems and leaves of Platycodon grandiflorum using 4 kinds of animal models of acute inflammation which were consisted of rats’footpad swelling induced by egg white,ear swelling caused by xylene in mice,celiac capillary permeation in mice induced by 1%glacial acetic acid and the analgesia experiments of hot plate method.[Results]Water extract of the stems and leaves of Platycodon grandiflorum had a certain degree inhibition effect on ear swelling caused by xylene in mice,rats’footpad swelling induced by egg white and celiac capillary permeation in mice induced by acute inflammation.Compared with model group,low-dosage and highdosage groups of water extract of the stems and leaves of Platycodon grandiflorum were of significant differences(P<0.05 or P<0.01).[Conclusions]Water extract of the stems and leaves of Platycodon grandiflorum had strong anti-inflammatory effects. [Objective] To study anti-inflammatory effects of water extract of the stems and leaves of Platycodon grandiflorum. [Methods] Observed anti-inflammatory effects of water extract of the stems and leaves of Platycodon grandiflorum using 4 kinds of animal models of acute inflammation which were consisted of rats’footpad swelling induced by egg white, ear swelling caused by xylene in mice, celiac capillary permeation in mice induced by 1% glacial acetic acid and the analgesia experiments of hot plate method. [Results] Water extract of the stems and leaves of Platycodon grandiflorum had a certain degree inhibition effect on ear swelling caused by xylene in mice, rats’ footpad swelling induced by egg white and celiac capillary permeation in mice induced by acute inflammation. Compared with model group, low-dosage and highdosage groups of water extract of the stems and leaves of Platycodon grandiflorum were of significant differences (P <0.05 or P <0.01). [Conclusions] Water extract of the stems and leaves of Platycodon grandiflorum had strong anti-inflammatory effects.