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早在1985年,Muller等即已发现,清晨血压过度升高,可能是清晨时段心血管事件发生率显著升高的主要原因。清晨高血压也是导致高血压患者靶器官损害的重要因素[1]。清晨血压过度升高是交感神经活性增加、肾素血管紧张素系统激活、血管内皮功能下降等多种因素综合作用的结果。而且,有研究表明清晨血压升高的幅度与血小板聚集程度密切相关,同时清晨血压过度升高也会造成血管僵硬度、血管炎症以及易损斑块增加[2-3]。清晨血压升高是促发心脑血管事件
As early as 1985, Muller et al. Discovered that excessive morning blood pressure may be the main reason for the significant increase of cardiovascular events in early morning hours. Early morning hypertension is also an important factor leading to the target organ damage in hypertensive patients [1]. Early morning blood pressure is increased sympathetic activity, renin-angiotensin system activation, decreased endothelial function and other factors combined results. Moreover, studies have shown that the magnitude of early morning blood pressure is closely related to the degree of platelet aggregation, while excessive blood pressure in the morning will lead to vascular stiffness, vascular inflammation and increased vulnerability to plaque [2-3]. Morning high blood pressure is to promote cardiovascular events