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目的探讨短期持续皮下胰岛素输注(CSII)与每日多次皮下注射胰岛素(MSII)对明显高血糖的2型糖尿病(T2DM)患者的疗效。方法比较CSII与MSII两种方法治疗前后血糖达标时间、胰岛素用量和低血糖发生次数。结果两种方法均能有效降低血糖,但达标时胰岛素总用量CSII组显著少于MSII组,控制血糖所需时间CSII显著少于MSII组,低血糖发生率CSII组显著低于MSII组。结论 CSII强化治疗T2DM更能较快平稳控制血糖,优于MSII治疗,并可减少低血糖发生的风险。
Objective To investigate the efficacy of short-term continuous subcutaneous insulin infusion (CSII) and multiple daily subcutaneous injections of insulin (MSII) in patients with type 2 diabetes mellitus (T2DM) with marked hyperglycemia. Methods Compared with the two methods of CSII and MSII before and after treatment of blood glucose compliance time, insulin dosage and frequency of hypoglycemia. Results Both methods could effectively reduce blood glucose. However, the total amount of insulin in CSII group was significantly less than that in MSII group at the time of reaching the standard. The time required for blood glucose control was less than that in MSII group. The incidence of hypoglycemia in CSII group was significantly lower than that in MSII group. Conclusion Intensive treatment of T2DM with CSII can control blood glucose more rapidly and steadily, which is better than MSII treatment and reduce the risk of hypoglycemia.