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目的比较不同化疗方案治疗老年非小细胞肺癌的疗效。方法回顾性分析接受化疗的老年晚期非小细胞肺癌61例的临床资料。结果 61例老年非小细胞肺癌的化疗有效率31.1%,KPS评分改善率37.7%。骨髓抑制:白细胞减少Ⅰ~Ⅱ度57.4%,Ⅲ~Ⅳ度6.6%;血小板减少Ⅰ~Ⅱ度47.7%;贫血Ⅰ~Ⅱ度33.4%。消化道反应:恶心呕吐Ⅰ~Ⅱ度29.3%,Ⅲ~Ⅳ度6.7%。未出现化疗相关死亡。结论本组化疗方案治疗老年晚期非小细胞肺癌疗效好,毒副反应可耐受;对于有较好器官功能的老年晚期非小细胞肺癌患者可考虑给予化疗。
Objective To compare the efficacy of different chemotherapy regimens in the treatment of elderly patients with non-small cell lung cancer. Methods The clinical data of 61 elderly patients with advanced non-small cell lung cancer undergoing chemotherapy were retrospectively analyzed. Results The effective rate of chemotherapy for 31 cases of non-small cell lung cancer was 31.1%, and the improvement rate of KPS score was 37.7%. Myelosuppression: leukopenia was 57.4% in degree I~II, degree in III~IV was 6.6%, 47.7% in degree I~II of thrombocytopenia, and 33.4% in degree I~II of anemia. Gastrointestinal reaction: Nausea and vomiting 29.3% in degree I~II and degree 6.7% in III~IV. No chemotherapy-related deaths occurred. Conclusions The chemotherapy regimen for elderly patients with advanced non-small cell lung cancer has good curative effect and toxic and side effects can be tolerated. Chemotherapy can be considered for elderly patients with advanced non-small cell lung cancer with better organ function.