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近年来人们一直在寻求用一种细胞取代梗死的心肌细胞以期维持正常的心脏功能。研究发现 ,胚胎干细胞 (ES)因牵涉伦理问题应用受限 ;胎儿心肌细胞对缺血耐受性差 ;骨骼肌细胞分化成熟后无法与宿主细胞建立电机械耦联 ;心脏的干细胞数量太少。相比之下骨髓间充质干细胞 (MSCs)不
In recent years, people have been seeking to replace infarcted cardiomyocytes with one kind of cells in order to maintain normal heart function. The study found that embryonic stem cells (ES) are limited due to ethical issues involved; fetal cardiomyocytes are poorly ischemic; skeletal muscle cells are unable to establish an electromechanical coupling with host cells after differentiation; and too few cardiac stem cells. In contrast, bone marrow mesenchymal stem cells (MSCs) do not