论文部分内容阅读
本研究采用直接法制备和分析了２０例原发性肝癌实体瘤Ｇ带染色体，每例实体瘤都有明显的染色体数目和结构异常。常见出现结构异常的染色体有１、２、３、７、和１１，９０％（１８例）的实体瘤有１号染色体长短臂不同程度的缺失和重排，２号染色体异常在８０％的实体瘤出现，尤以２ｐ－为突出。本研究所见提示各种染色体的缺失和重排特别是１号染色体的改变、２号和７号染色体短臂的缺失，可能是引起多个原癌基因的激活和抑癌基因失活的基础。
In this study, we prepared and analyzed G-band chromosomes of 20 cases of primary hepatocellular carcinoma with direct method. Each solid tumor has obvious chromosome number and structural abnormalities. Common structural abnormalities in chromosomes 1, 2, 3, 7, and 11, 90% (18 cases) of solid tumors have different lengths of short and long arms of chromosome 1 deletions and rearrangements, chromosome 2 abnormalities in 80% of entities Tumors appear, especially 2p- for the prominent. The findings of this study suggest that deletion and rearrangement of various chromosomes, especially chromosome 1 alterations, and absence of short arms on chromosomes 2 and 7 may be the basis for the activation of multiple protooncogenes and the inactivation of tumor suppressor genes .