应用ＭＡ７３－２３４乳腺癌津白Ⅱ号小鼠动物模型，探讨了随病程进展而不断增大的肿瘤负荷对Ｍφ抗瘤效应如Ｍφ分泌的ＩＬ－１活性水平、Ｍφ吞噬功能ＭＭＡＤＣＣ效应的动态影响。结果发现，Ｍφ分泌的ＩＬ－１活性水平在病程早期即明显下降，提示该功能更易受到肿瘤负荷的影响，从而可能会中枢性地抑制宿主免疫系统抗肿瘤效应的发挥，成为逃避宿主免疫工攻击的分子机制之一；而Ｍφ吞噬功能、ＭＭＡＤＣＣ效应在病程早期或中期当肿瘤负荷较小时有所加强，而晚期在肿瘤负荷较大时则减弱。 The animal model of MA73-234 breast cancer Jinbai Ⅱ mice was used to investigate the effect of increasing tumor burden on the anti-tumor effect of Mφ, such as the level of IL-1 secreted by Mφ and the dynamic effect of Mφ phagocytosis MMADCC . The results showed that the level of IL-1 secreted by Mφ decreased significantly at the early stage of the disease, suggesting that this function is more likely to be affected by tumor burden, which may inhibit the antitumor effect of the host immune system in a central way and become evade host immune attack Mφ phagocytosis, MMADCC effect in the early or mid-course of the disease when the tumor load is smaller, while the late tumor load is larger, weakened.