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目的探讨消化性溃疡并急性上消化道大出血应用大剂量泮托拉唑的临床效果。方法 2009年1月至2011年1月收治的消化性溃疡并急性上消化道大出血患者108例,依据治疗方法分为大剂量组58例,常规剂量组50例,观察两组病例12h、24h、48h消化道出血停止情况。结果两组12h、24h、48h消化道出血止血成功率比较差异有统计学意义(P<0.05)。结论在消化性溃疡并急性上消化道大出血早期大量应用泮托拉唑能够有效提高止血成功率,缩短止血时间,改善临床症状,临床疗效更确切。
Objective To investigate the clinical effect of high-dose pantoprazole on peptic ulcer and acute upper gastrointestinal hemorrhage. Methods A total of 108 patients with peptic ulcer and acute upper gastrointestinal bleeding who were treated from January 2009 to January 2011 were divided into high dose group (58 cases) and conventional dose group (50 cases) according to the treatment method. The patients in two groups were observed for 12h, 24h, 48h gastrointestinal bleeding stopped. Results The success rate of hemostasis in digestive tract hemorrhage between the two groups at 12h, 24h and 48h was significantly different (P <0.05). Conclusions In the early stage of peptic ulcer and acute upper gastrointestinal hemorrhage, extensive application of pantoprazole can effectively improve the success rate of hemostasis, shorten the time of hemostasis and improve clinical symptoms, and the clinical curative effect is more exact.