腔道肿瘤微波热疗中有效治疗体积与冷却水温关系研究

来源 :中国医学物理学杂志 | 被引量 : 0次 | 上传用户:Zeshawn
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肿瘤热疗可用活组织中的有效治疗深度ETD(如: 定义为温度在41~45℃范围的距离)和有效治疗体积ETV(定义为相应于有效治疗温度范围的体积)来衡量一次加热治疗的优劣及满意程度,但在实测时常难以实现。本文根据腔内水冷式微波偶极子辐射器近场辐射模型,求解生物介质热传导方程,运用数值计算方法得到水冷式腔道辐射器在等效组织模型中的稳态温度分布; 并对腔道肿瘤微波热疗时有效治疗体积与冷却水温关系进行仿真计算研究。结果表明:水冷可改善热区温度分布,使径向最高温度点由无水冷时贴近辐射器壁向组织深部迁移(本文示例当冷却水温Tc= 16℃时可达6 m m 以远);径向治疗深度比无水冷时向组织内部扩展(上述冷却水温下可达3~4 m m 左右); 相应的有效治疗体积则比无水冷时增加(上述条件下约为39% ); 降低冷却水温(本文示例从16℃降至10℃), 则相应的有效治疗深度又可向组织内部扩展; 有效治疗体积还可增加(约再增33% )。由此引伸出在一次加热治疗时,若采取两步加热法, 即先用低功率、无水冷加热,后用高功率有循环水冷的加热程序,则总有效治疗体积可比完全无水冷时扩大1.24 倍(约增加4.3 cm 3)。本文模拟计算结果与相应的等效肌肉 Tumor hyperthermia can be measured by the effective treatment of deep ETD in living tissue (eg, defined as a temperature in the range of 41 to 45° C.) and the effective therapeutic volume ETV (defined as the volume corresponding to the effective therapeutic temperature range) to measure the heat of treatment. Advantages and disadvantages and degree of satisfaction, but it is often difficult to achieve in the actual measurement. In this paper, the near-field radiation model of water-cooled microwave dipole radiator is used to solve the equation of heat transfer in biological media. The steady-state temperature distribution of the water-cooled cavity radiator in the equivalent tissue model is obtained by numerical calculation. The relationship between effective treatment volume and cooling water temperature during tumor microwave hyperthermia was studied by simulation. The results show that the water cooling can improve the temperature distribution in the hot zone, and the maximum radial temperature point migrates from the wall near the radiator to the deep part of the tissue when it is not cooled (this example shows that when the cooling water temperature is Tc = 16°C, it can reach 6 m far); When the depth of treatment is colder than that of waterlessness, it expands into the interior of the tissue (about 3 to 4 m m at the above cooling water temperature); the corresponding effective treatment volume is increased when compared with no water cooling (about 39% under the above conditions); Reducing cooling water temperature (Examples from this article are reduced from 16 °C to 10 °C), the corresponding effective depth of treatment can be extended to the inside of the tissue; the effective treatment volume can also increase (about 33% increase again). This leads to a heating treatment, if you take a two-step heating method, that is, first with low power, anhydrous cold heating, followed by a high-power heating program with a recirculating water, the total effective treatment volume can be extended than when completely anhydrous cold 1 .24 times (about 4.3 cm 3 more). This article simulates the calculation results and the corresponding equivalent muscle
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