关于颗粒细胞肿瘤及其它病变的性质、来源问题,一直存在争议。本文通过对口腔及颌骨的粘膜颗粒细胞肿瘤,颗粒细胞型造釉细胞瘤,新生儿先天性龈瘤和一些具有颗粒细胞性变的扁平苔藓进行了临床病理、免疫组化和超微结构研究后,在免疫组化方面提示:除新生儿的龈瘤为间叶源性外,上述其它病损则起源于雪旺氏细胞或原始的间叶细胞。由于牙源性上皮和雪旺氏细胞都起源于神经嵴,所以作者推测所有的颗粒细胞是从神 There have been controversies about the nature and origin of granulosa cell tumors and other pathologies. In this paper, clinicopathologic, immunohistochemical and ultrastructural studies of mucosal granulosa cell tumors, granulocyte-type ameloblastomas, neonatal congenital neoplasms, and lichen planus with granulosa cell changes in the oral cavity and jaw bone were performed. Later, in terms of immunohistochemistry, it was suggested that in addition to neoplasms of neonates with mesenchymal origin, the above other lesions originated from Schwann cells or primitive mesenchymal cells. Since both odontogenic epithelium and Schwann cells originate from neural crest, the authors speculate that all granule cells are from